白癜风与正常皮肤相比，计算机图像分析的临床和组织病理

背景：虽然许多研究都集中在皮肤白斑病灶周围，显然是正常的皮肤遥远研究仍然很少有争议。

The degree of involvement of these areas and the size of the affected surface area considerably influence strategies of therapeutic options.

这些领域的参与程度的和受影响的表面积的大小显着影响的治疗选择的策略。

Objective: To compare and correlate colour and histopathological melanin changes in lesional, perilesional skin with distant skin of vitiligo patients using computerized image analysis.

目的：比较和关联的白癜风患者，采用计算机图像分析与远方的皮肤颜色和病理病灶，病灶周围皮肤黑色素的变化。

Patients and methods: Forty vitiligo patients were included.

病人和方法：40例白癜风患者都包括在内。

For each patient, three different areas were considered: the lesional, the perilesional and apparently normal distant skin.

对于每一个病人，被认为是三个不同的领域：皮损，遥远的皮肤病灶周围，显然是正常的。

In each patient, computerized image analysis was carried out for clinical photos and for histopathology of biopsied skin specimens stained with haematoxylin and eosin and Fontana-Masson.

在每一个病人，进行计算机图像分析为临床照片和病理组织学活检皮肤标本染色与苏木精和曙红和Fontana马尾松。

Results: There was a statistically significant difference in skin colour changes and histopathological pattern between lesional, perilesional skin and distant skin that correlated with disease duration.

结果：皮肤颜色改变病灶，病灶周围皮肤和远处的皮肤，与病程及病理组织学模式之间有一个统计上的显着差异。

Conclusion: Perilesional skin and apparently normal distant skin in vitiligo patients are involved in the same pathological process affecting lesional skin and this is reflected in both morphological and histopathological patterns but with different degrees.

结论：白癜风患者的病灶周围皮肤和皮肤显然是正常的遥远参与在相同的影响皮损，这反映在形态和组织病理学的模式，但有不同程度的病理过程。